July 17, 2006

Word defined: activase

If your heart is all tied up in knots,
You may need to take activase shots.
Explained Doctor Yasmin,
"It helps produce plasmin,
An enzyme that breaks fibrin clots!"

Activase is a recombinant tissue-plasminogen activator (rt-PA)—a thrombolytic indicated for use in patients with acute myocardial infarction (AMI), acute ischemic stroke, and acute, massive pulmonary embolism. Approved in 1996, Activase remains the only drug indicated for the treatment of stroke.

Activase works by stimulating the body's own clot-dissolving mechanism by activating plasminogen, a naturally occurring substance secreted by endothelial cells in response to injury to the artery walls that contributes to clot formation.

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